1、南昌大學醫(yī)學院碩士學位論文Artemin、GFRα3在胰腺癌中的表達與胰腺癌神經(jīng)浸潤轉移的相關性研究姓名：朱棟良申請學位級別：碩士專業(yè)：外科學（普外科）指導教師：羅地來20090501AbstractABSTRACTObjective：ToinvestigatethedependablitybetweentheexpressionofArteminandGFRct3andperineuralinvasionandmetastasisof

2、pancreaticcarcinomaMethods：Semiquantitativereversetranscriptionpolymerasechainreaction(RTPCR)andImmunohistechemicalSP(streptavidin—perosidase)methodWasusedtodetecttheexpressionofArteminandGFRo[3intisuesofpancreaticcarcin

3、oma，paracarcinomatissuesandnormalpancreasToobservationthedependablitybetweenthepositiveexpressionofArteminandGFRot3andperineuralinvasion，metastasis，tumordifferentiationandotherindicatorsofclinicalpathologyofpancreaticcar

4、cinomaResults：ThepositiveexpressionofArteminandGFR0[3inpancreaticcarcinomawere(7209％，6744％)，whichweresignificantlyhigherthanthoseinparacarcinomatissue(1819％2273％，P005)TheexpressionofArteminmRNAinpancreaticcarcinomawere(0

5、7410014)，whichweresignificantlyhigherthanthoseinnormalpancreastissue(01010031)(PO05)ItshowedthatthepositiveratesofArteminmRNAexpressioninpatientswithperineuralinvasion(08430012)werehigherthanthatwithoutperineuralinvasion

6、(05120017)(尸005)Conclusions：TheexpressionofArteminandGFRot3mayplayanimportantroleinnervousinfilrtationofpancreaticcarcinoma，TheirexpressionmaybeausefullindicatorforthebiologicalbehaviorofpancreaticcarcinomaKeywords：pancr